- 1 About Zydus Cadila
- 2 Clinical Studies on Tadalafil
- 3 Description and Mechanism of Action of Tadalafil
- 4 Zydalis MD Effects for Erectile Dysfunction
- 5 Recommended Doses and Duration of Therapy
- 6 Side Effects and Warnings
- 7 Drug Interactions
- 8 Customer Reviews
- 9 Price, Available Forms and Zydalis MD Dosage
- 10 Reference List
- 11 Editor's Rating
Zydalis MD 10mg/20mg is a drug consisting of tadalafil as its active ingredient in order to treat problems associated with the sexual health of males.
The drug must be stored between a temperature range of 15 to 30 degree Celsius within an airtight jar. One tablet of Zydalis MD is enough on a daily basis which is to be used orally. The possible side effects associated with the use of Zydalis MD include a headache, myalgia, back pain, dyspepsia, stomach upset, and diarrhea.
About Zydus Cadila
Zydus Cadila is an Indian based company that came into being in 1952. The company deals in manufacturing of different active pharmaceutical products, animal products, and different formulations of drugs. The company enjoys the honor of being the only pharmaceutical business in India that has launched its own original drug for treating dyslipidemia due to diabetes. Drugs are manufactured by this company in different formulations like soft capsules, Tablets, hard capsules, sterile liquids, injectables, transdermal patches, inhalers, suppositories and different vaccines.
The company aspires to become research-based by the year 2020. In 2011, Zydus Cadila made its entry to the group of companies that have a turnover rate of a billion Dollars. It is also considered to be the fourth largest pharmaceutical company in India. Drugs related to different fields of medicine are manufactured here like Diabetes, CVs drugs, drugs for inflammation, anti-cancer drugs, pain management drugs, etc. It also ships its products worldwide to different countries like Brazil, the United States, France, South Africa, Brazil, etc. 
Clinical Studies on Tadalafil
A research study titled as “Tadalafil-sensitive impairment in muscle blood flow during exercise in Duchenne Muscular Dystrophy” was conducted by Michael Nelson et al that focused on an aspect of tadalafil to cause a blockage in blood flow in patients suffering from Duchenne Muscular Dystrophy. Duchenne Muscular Dystrophy is a disease that is mainly caused by any mutation in the “dystrophin” gene which is out of the frame. This is an X-linked disease in which the patient suffering from it undergoes a wasting of his muscles. There is no particular treatment discovered for Duchenne Muscular Dystrophy by now apart from the use of corticosteroids. The patients who are suffering from Duchenne Muscular Dystrophy are completely devoid of a muscle protein known as dystrophin and this lack of dystrophin results in an impairment of nNOS in its normal work of targeting sarcolemma by which the muscles get their main supply of nitric oxide (NO). It has been known by now that due to impairment in the targeting of nNOS, the dystrophic skeletal muscles fail to experience a shrinking of reflex vasoconstriction that is induced by exercise in these muscles. This associates the pathogenesis of Duchenne Muscular Dystrophy with a supposed vascular component. In this study, information was presented using the second phenotype and it was said that the blood flow in the boys suffering from Duchenne Muscular Dystrophy when measured by Doppler ultrasound of brachial artery failed to increase when they underwent an exercise involving a mild handgrip. The role of tadalafil was also established in this study which was established as an agent that removed hyperemia in these patients suffering from Duchenne Muscular Dystrophy in a manner of dose dependence. This study concluded a therapy with PDE5 as an important therapy for treating this muscular disease. 
“Tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model” is a study conducted by Xu Ziqiang et al which discusses the effect of tadalafil on arteriosclerosis of a graft in a rat. It is known that tadalafil can be used to regain the function of the endothelium of a vessel and also in the treatment of arteriosclerosis. However, it is not known how tadalafil affects the arteriosclerosis that is developed on a tissue that has been grafted. Male Brow-Norway rats were selected in this study that gave their aorta grafts to male Lewis rats. These rats were split into three groups; a control group that received saline, a group of rats that was given tadalafil in low doses i.e. 0.5 mg per kg every day and the last group that was given tadalafil in high doses which were 1 mg per kg on a daily basis. The therapy went on for some time and after 8 weeks following the transplantation; the graft was taken out of these rats and was analyzed using different tests. The level of cGMP was tested in these samples by using the process of ELISA. It was seen that administration of tadalafil in these rats resulted in a decrease of the thickness in the aorta of them. In addition to this, tadalafil also seemed to increase the concentration of cGMP and the cGMP-dependent kinase enzyme in these rats. It was concluded that tadalafil can reduce the incidence of arteriosclerosis in graft tissue in rats. 
Description and Mechanism of Action of Tadalafil
Tadalafil works by inhibiting the production of an enzyme usually known as phosphodiesterase 5 (PDE5) which is accountable for the breakdown of cGMP in the corpus cavernosum which is positioned around the penis. The erections experienced by the person when he is sexually stimulated is caused by an augmented flow of blood towards the penis seen when arteries are dilated. This dilatation of penile arteries occurs when Nitric Oxide (NO) is produced in the penile tissue. NO once produced causes an increased production of cGMP in the corpus cavernosum which leads to the production of a relaxing effect on the muscles of the penis. PDE5 inhibits the accumulation of cGMP and the effects produced by it and tadalafil helps to inhibit this enzyme from working in order to treat ED. 
Zydalis MD Effects for Erectile Dysfunction
Tadalafil is primarily used to help the patients get rid of all the problems related to his sexual health. Administration of tadalafil in the body assists the patient in attaining an erection that is hard and stays for a long period of time. This ensures that the patients suffering from the problem of erectile dysfunction can enjoy their sexual life to the fullest without having to worry about anything. It also treats ejaculation disorders and impotence in males. Benign prostatic hyperplasia is another indication for the usage of tadalafil which additionally treats other urinary problems related to tadalafil as well. In males and females suffering from pulmonary arterial hypertension, this drug is of great use. 
Recommended Doses and Duration of Therapy
Zydalis MD is offered in the form of tablets that are directed to be taken orally. These tablets must be placed in the mouth and swallowed with the help of a glass of plain water without chewing or crushing. These tablets can be taken with or without having a meal and one tablet is enough for a single day to achieve the desired effects. The patient must consume one tablet of Zydalis MD about half an hour prior to an anticipated sexual intercourse in 10 mg or 20 mg potency according to the severity of ED. 
Side Effects and Warnings
<div class=”my-quotes”>Use of Zydalis MD can cause a headache, stomach upset, dizziness and painful erections sometimes.</div> The patient using it can report back pain, myalgia, and indigestion as well. The face can be flushed and nasal congestion can occur along with a pounding sensation in the chest. In some patients, hypersensitivity reactions can also be observed while some cases report visual disturbances and hearing loss in patients using Zydalis MD. 
Zydalis MD should not be taken with certain drugs like rifampicin, carbamazepine, barbiturates, and efavirenz because these medicines are the inducers of the liver enzymes and cause a decreased concentration of Zydalis MD in the blood. Other drugs which can cross react with Zydalis include rifabutin, phenobarbital, phenytoin, and nevirapine. Antibiotics like clarithromycin and azole antifungal drugs like itraconazole and ketoconazole should also not be used with Zydalis MD for a risk of cross-reactivity. Cimetidine and certain protease inhibiting drugs used in the treatment of HIV infection should also be avoided. Zydalis MD should also not be used with other drugs meant to treat ED in addition to nitrates as both of them can cause a development of additional hypotensive effects in the body. 
Customer reviews are the first and foremost part that is checked by a customer who is eager to try out a new drug. This is due to the fact that the information given in these feedback reviews is not biased and is not based on mere scientific research but comprises of actual experiences that the customers have had with that particular drug. That is why the presence of good customer reviews about a certain drug makes it a popular and a valuable drug and allows a customer to put his faith into it. Zydalis MD did not have any customer reviews made in its name; therefore, nothing could be said for certain about this drug. It is recommended not to use Zydalis MD unless it gets some credibility and choose some popular tadalafil drugs instead.
Price, Available Forms and Zydalis MD Dosage
The availability of Zydalis MD does not seem to be an issue since the drug is offered for purchase by a number of drug stores that are working online. It can be purchased at a price of 1.34 US Dollar per pill consisting of 10 mg of tadalafil in it.
Some other pharmacies are also providing shipping for the convenience of people residing in countries other than India that includes the United States, Australia, and Canada. Slow shipping allows the customer to receive his drug in a month and it charges him 30 USD. Fast shipping takes 1 to 2 weeks to deliver the shipment but is a bit pricey i.e. 60 US Dollars per shipment.
Zydalis MD is available on the market in the form of tablets consisting of either 1o mg or 20 mg of tadalafil. The dose of tadalafil when it needs to be used on a daily basis is set at 2.5 mg for a regular person. However, those who are suffering from an intense form of erectile dysfunction can use up to 5 mg of tadalafil on a daily basis to treat it.
- About us [Internet]. Zyduscadila.com. Retrieved from: http://zyduscadila.com/
- Nelson M, Martin EA, Tang X, Johannes J, Lewis J, Gurudevan SV, Victor RG. Tadalafil-sensitive impairment in muscle blood flow during exercise in Duchenne Muscular Dystrophy. The FASEB Journal. 2013 Apr 1;27(1 Supplement):943-17.Retrieved from: http://www.fasebj.org/content/27/1_Supplement/943.17.short
- Ziqiang X, Jingjun W, Jianjian Z, Yong L, Peng X. Tadalafil attenuates graft arteriosclerosis of aortic transplant in a rat model. Iranian journal of basic medical sciences. 2015 Sep;18(9):927. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620194/
- Zydalis MD Actions [Internet]. Ndrugs.com. Retrieved from: http://www.ndrugs.com/?s=zydalis%20md&t=actions
- Zydalis MD 10mg tabs [Internet]. 1mg.com. Retrieved from: https://www.1mg.com/drugs/zydalis-md-10mg-tablet-73804
- Zydalis MD 10mg tabs [Internet]. Medplusmart.com. Retrieved from: http://www.medplusmart.com/product/ZYDALIS-MD-10-TABLET/ZYDA0001
- Zydalis Md(20mg) [Internet]. Drugbook.com. Retrieved from: http://drugbook.in/zydalis-md20mg.html
- Zydalis MD 10mg tabs [Internet]. Medsplan.com. Retrieved from: http://www.medsplan.com/DrugsDetailsPage/ZYDALIS-MD-10-mg/Tadalafil