- 1 About Cadila Pharmaceuticals Ltd.
- 2 Scientific Studies on Tadalafil
- 3 How Tadalafil Works?
- 4 Zydalis Effects for Erectile Dysfunction
- 5 Recommended Doses and Duration of Therapy
- 6 Toxic Effects and Precautions
- 7 Drug Interactions
- 8 Customer Reviews
- 9 Price, Available Forms and Dosage
- 10 Reference List
- 11 Editor's Rating
Zydalis 10mg/20mg tablets are a drug used for treating problems related to the male sexual health. These problems include benign prostatic hyperplasia, erectile dysfunction, and impotence.
Zydalis ought to be taken orally and one tablet is sufficient for a day to gain the required results. The pill is well absorbed and distributed widely to the tissues of the body in a short period of time. Some side effects that can be experienced while using this drug include nasal congestion, dyspepsia, nausea, myalgia and a headache.
About Cadila Pharmaceuticals Ltd.
Founded in 1951, the headquarters of Cadila Pharmaceuticals Ltd. are located in Ahmadabad, India. being one of the biggest private pharmaceutical companies of India, Cadila Pharmaceuticals is currently providing its products to over 85 other countries around the world.
The products manufactured by this pharmacy cover 45 different therapeutic areas of medicine which revolve around 12 specialties. These specialties include drugs related to the CVS, anti-infective drugs, antibiotics, gastrointestinal drugs, haematinics, drugs related to pain management and more. The company owns its own research and development section which has enrolled over 300 scientists who are working hard to bring innovation to the field of medicine. The manufacturing unit of this company located in Gujarat has been able to achieve an approval by the USFDA. Cadila Pharmaceuticals aspires to become the leading company in India by providing its valued customers with best drugs within affordable range. 
Scientific Studies on Tadalafil
A research study named as “Evaluation of sexual activity in patients treated with tadalafil: a randomized prospective placebo-controlled trial” supervised by A F De Rose et al focused on the effects produced by Tadalafil on the sexual activity of patients suffering from erectile dysfunction. Tadalafil has been proven to possess characteristics of treating the problem of sexual dysfunction in men due to its property of inhibiting the enzyme named PDE5. This study was aimed to find out what effects does Tadalafil bring about in the capacity of performing a sexual activity in males when administered into them. A group of male volunteers who were suffering from erectile dysfunction were selected in order to pursue this study. These sick persons were separated into two different groups based on what they received. One group of the patients received Tadalafil while the other group was set to receive placebo. The therapy had to be continued for 3 months after which results were to be evaluated. A total of 120 people took part in this study that was randomly decided to either receive tadalafil in 20 mg dose or placebo only on two days of a week i.e. Friday and Tuesday. International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) were the parameters on the basis of which improvements were to be checked in these patients after 3 months. It was seen that the three-month therapy with tadalafil resulted in significant improvement in the IIEF and SEP scores in the patients as seen with the improvements seen in patients who received placebo. An account of all the successful intercourses was taken in people using tadalafil and it was found that highest number of these successful attempts were made in 6 to 12 hours following the use of tadalafil and these declined a little but still remained quite high during the 12 to 28-hour time range. It was also concluded that the patients who successfully attempted an intercourse up to 6 hours after tadalafil consumption engaged in it on an average of 6 to 24 hours. 
“Tadalafil Once Daily Improves Ejaculatory Function, Erectile Function, and Sexual Satisfaction in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia and Erectile Dysfunction: Results from a Randomized, Placebo- and Tamsulosin-Controlled, 12-Week Double-Blind Study” by François Giuliano et al focused on the extensive therapeutic effects accomplished by administration of tadalafil only once on a daily basis. This was established by comparing the results of tadalafil on a group of people suffering from sexual problems and the results were compared with the effects of tamsulosin and placebo-treated people suffering from the same set of sexual problems. People who were chosen for this study were mainly suffering from the problem of benign prostatic hyperplasia along with lower urinary tract symptoms. These people were divided into three groups, the first group received tadalafil in 5 mg dose on a daily basis while the other group received 0.4 mg of tamsulosin as a control. The third group was placebo-treated and all of these groups underwent the therapy for about 12 weeks. International Index of Erectile Function was set to be the basis of drawing a conclusion in this case and these sick persons were subjected to fill out a questionnaire based on IIEF just before starting the treatment and repeated at 4th, 8th and 12th week of therapy. These people were thoroughly examined for the effects of any of the three agents administered on their erectile dysfunction, satisfaction level, ejaculation, and orgasm. The results were recorded for the three groups separately and were later compared. It was seen that the group that received tadalafil during the therapy showed maximum improvement in their erectile dysfunction, orgasm, and satisfaction level. The patients who received tamsulosin rather showed a decrease in the regularity of ejaculation and orgasm when compared to the placebo-treated group. 
How Tadalafil Works?
The mechanism by which tadalafil produces its therapeutic effects is due to its property of inhibiting an enzyme known as phosphodiesterase 5. The enzyme is responsible for breaking down cGMP in the muscle cells of the prostate as well as the penis. Tadalafil hinders the normal activity of PDE5 and enhances the levels of cGMP which bring about relaxation in the smooth muscles of penis and prostate. It also causes vasodilatation of the arteries that carry blood towards the penis consequently enhancing the total blood supply towards it and producing strong erections. 
Zydalis Effects for Erectile Dysfunction
Tadalafil is implied for various benefits in males and to some extent in females as well. it helps the patient to maintain and erection by increasing the flow of blood towards the penis. in this way, it helps the patient in treating erectile dysfunction and consequently impotence. it can also be used in people who are suffering from benign prostatic hyperplasia. it helps to reduce the abnormally large size of the penis as well as treat other problems like scanty urination, hesitation to start urinating and much more. In men and women, it can be used to treat the problem of pulmonary arterial hypertension 
Recommended Doses and Duration of Therapy
Zydalis is manufactured in the form of tablets which are to be taken via the oral route. The dose of the tablet i.e. 10 mg or 20 mg is decided on the basis of severity of the ED problem. However, only one tablet is advised to be taken per day 30 minutes before engaging in a sexual activity. For those who are taking other drugs which inhibit liver enzymes, 10 mg of this drug should be taken every 3 days. 
Toxic Effects and Precautions
Flushing of the face is seen with nasal congestion. Tinnitus and loss of hearing are also observed in some cases. in rare cases, the drug is capable of causing MI, CVS events, and stroke. Hyperemia of the conjunctiva and swelling in eyelids can also be seen in some patients. 
Concurrent use of Zydalis with certain alpha-blockers can cause an increase in the risk of hypotension in patients. It causes an augmented danger of priapism when used with other medicines for erectile dysfunction. Use of theophylline with Zydalis is not advised along with some other drugs like rifampicin, carbamazepine, efavirenz, nevirapine, phenobarbital, barbiturates, rifabutin and phenytoin which are inducers of liver enzymes. Azole antifungals, cimetidine, protease inhibitors and macrolides can cause drug interactions with Zydalis along with nitrates and nitroglycerin which can enhance its effect of causing hypotension.
No customer reviews could be derived from any website present online for Zydalis 10 mg tablets. Customer reviews are important because of the fact that these are the only source of information that can be completely relied on. The customers who give these reviews are regular people who share their real live experience of a particular drug despite being differential to the manufacturer. The drugs which are completely devoid of these reviews must not be trusted blindly for they can be potentially dangerous. Therefore, it is advised not to use Zydalis without any confirmation and other drugs should be preferred instead that consist of Tadalafil as their active pharmaceutical agent.
Price, Available Forms and Dosage
A number of pharmacy stores exist online that are involved in the sale of Zydalis. Zydalis can be bought at in different amounts like 10 pills, 20 pills, 60 pills, etc. per unit price of Zydalis on ordering 10 tablets of it is set at 3.49 US Dollars. As the number of pills in particular order increases, the unit prices of Zydalis decrease that gives the customers a chance to avail discount on bulk orders.
Zydalis is also being offered at some pharmacy stores for shipping to all the parts of the world including the United States, Canada and Australia. Two methods of delivery are available for the customers to choose from i.e. Airmail that costs 9.95 USD and the EMS that charges 19.95 USD for its services.
Zydalis can be taken as tablets that consist of tadalafil as their active ingredient. If a patient wants to use tadalafil on a daily basis in order to treat his erectile dysfunction, he must use it in a dose of 2.5 mg every day. While dealing with a severe form of ED, the dose can be adjusted to 5 mg but no more than this is advised to be taken the same day.
- About us [Internet]. Cadilapharma.com. Available from: http://cadilapharma.com/about-us/
- De Rose AF, Gallo F, Carmignani G. Evaluation of sexual activity in patients treated with tadalafil: a randomized prospective placebo-controlled trial. International journal of impotence research. 2005 Jan 1;17(1):76-9. Available from: http://www.nature.com/ijir/journal/v17/n1/full/3901265a.html
- Giuliano F, Oelke M, Jungwirth A, Hatzimouratidis K, Watts S, Cox D, Viktrup L. Tadalafil once daily improves ejaculatory function, erectile function, and sexual satisfaction in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia and erectile dysfunction: Results from a randomized, placebo‐and tamsulosin‐controlled, 12‐week double‐blind study. The journal of sexual medicine. 2013 Mar 1;10(3):857-65. Available from: http://onlinelibrary.wiley.com/doi/10.1111/jsm.12039/full
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- Tadaforce Tablet Review [Internet]. Medindia.net. Available from: http://www.medindia.net/doctors/drug_information/tadalafil.htm#whentouse
- Zydalis 10mg tabs [Internet]. Medidart.com. Available from: https://www.medidart.com/products/ZYDALIS-10MG-TAB4.html
- Zydalis [Internet]. Mediangels.com. Available from: http://www.mediangels.com/drugs/zydalis/30316