- 1 Manufacturer’s Profile: Health Guard (I) Pvt. Ltd
- 2 Scientific Studies on Tadalafil
- 3 Description and Mechanism of Action of Tadalafil
- 4 Tadagra Effects for Erectile Dysfunction Patients
- 5 Duration of Therapy and Prescribed Doses
- 6 Side Effects to Expect and Warnings
- 7 Drug-to-Drug Interactions
- 8 Customer Reviews
- 9 Price, Available Forms and Dosage
- 10 Reference List
- 11 Editor's Rating
Tadagra 40mg/20mg is a drug that consists of tadalafil as its active ingredient.
It is also responsible for improving the sexual life of the person using it by helping him acquire hard, long lasting erections. The drug is manufactured in different forms including pills, tablets, and soft gelatin capsules providing the customers with a chance to choose whichever form they find more convenient.One tablet is usually used before indulging into a sexual activity and the effects usually last for the whole day. Pain in back, dyspepsia, headache and pain in the muscles can be felt by people as side effects when they consume Tadagra.
Manufacturer’s Profile: Health Guard (I) Pvt. Ltd
Health Guard (I) Pvt. Ltd has been operating for about 16 years with franchises spread all across India. it is involved in the manufacture of different forms of drugs like soft gel capsules, tablets, eye drops, cream, ointment, nasal drops, proteins, and liquids.
Health Guard (I) Pvt. Ltd deals in the manufacture of various antibiotics, antioxidants, hormones, proton pump inhibitors, drugs for liver, topical ointments and haematinics. The company claims to hold an approval from PGIMER Chandigarh and its products are successfully delivered to various hospitals and other institutions of India. Established since 1994, the company claims to follow the regulations of GMP in its manufacturing unit. The aim of this company is to expand its business worldwide and to satisfy its customers by producing high quality products. 
Scientific Studies on Tadalafil
A research titled as “Tadalafil for the treatment of pulmonary arterial hypertension” by Erika B Rosenzweig et al comprised of information based on the role of tadalafil in treating the disease of pulmonary arterial hypertension in people. Characteristically speaking, tadalafil is an inhibitor of an enzyme known as phosphodiesterase 5 and is a long acting drug which has been recently approved by the FDA for treatment of pulmonary arterial hypertension. The basic purpose of this research was to demonstrate the clinical efficacy and the safety of use of tadalafil by determining about its different properties after it has been administered into the body. The specific use of tadalafil in the treatment of pulmonary arterial hypertension was to be determined as compared to several other drugs that were being introduced for the treatment of the same disease. For proceeding this research, a detailed analysis of all the recent literature available on the use of tadalafil in patients suffering from pulmonary arterial hypertension was carried out. It was seen that FDA gave its full fledge approval for using tadalafil for treating pulmonary arterial hypertension in patients and later that it was fit to use for patients with pulmonary arterial hypertension. This was supported by the facts that administration of tadalafil I 40 mg dose in these patients not only improved the quality of their lives but also increased their capacity to exercise and reduced the worsening in such cases as well. It was the second agent with inhibitory properties of PDE5 approved by the FDA after sildenafil but it was thought to be more beneficial than it. This was due to the fact that tadalafil was longer acting and required one time administration per day in contrast to sildenafil which has a small duration of action. Therefore, tadalafil was concluded to be more compliant as well as cost-effective for patients. 
“Tadalafil for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia” by Ricardo R Gonzalez et al is a study that focused on the use of tadalafil in the treatment of problems of the lower urinary tract in patients suffering from benign prostatic hyperplasia. The research was carried out to find out about the pharmacological properties of tadalafil as well as evidence of its use in the treatment of benign prostatic hyperplasia. The use of tadalafil was considered because of the fact that all three of the problems i.e. benign prostatic hyperplasia, erectile dysfunction, and lower urinary tract symptoms tend to increase as a person ages. Secondly, it was known that the inhibition of the enzyme phosphodiesterase inhibitor 5 tends to produce relaxation in the muscles of the urinary tract which is important for the treatment. Lastly, there exists evidence in previously held studies that tadalafil can successfully treat problems of erectile dysfunction as well as of lower urinary tract. So, it is basically the common pathophysiology of lower urinary tract symptoms and erectile dysfunction that makes tadalafil of great use in treating both of them. In a recently conducted phase 2 trial, the effects of tadalafil as compared to placebo were observed and it was seen that the administration of tadalafil once on a daily basis treated benign prostatic hyperplasia as well as lower urinary tract symptoms caused by it in addition to treating erectile dysfunction. The fact that a single agent i.e. tadalafil is equally effective in treating erectile dysfunction as well as lower urinary tract symptoms is clinically significant, however, care in selecting patients as well as the establishment of more trials in this regard are suggested. 
Description and Mechanism of Action of Tadalafil
Tadalafil is a PDE5 inhibitor and helps to overcome the problem of erectile dysfunction by inhibiting this enzyme that would otherwise break cGMP in the penis of the patients. Cyclic Guanosine Monophosphate is a compound that tends to bind with different proteins occurring in the penile muscles and this brings about the relaxation in these muscles. It also dilates the arteries reaching the penis that results in an increased blood flow towards the penis. As soon as a person begins to get sexually stimulated, there is a production of acetylcholine along with nitric oxide in the penis which works with another enzyme to produce cGMP. In a diseased patient, PDE% immediately breaks down cGMP and does not let the person attain an erection. Tadalafil brings about a breakdown of this enzyme ensuring high levels of cGMP hence, treating ED. 
Tadagra Effects for Erectile Dysfunction Patients
Tadalafil can be used to treat different diseases related to the sexual health of the men. The most important indication of this agent is its use in erectile dysfunction and consequently in treating impotence. The use of tadalafil can hence, improve the sexual health of a person as it lets the patient enjoy his sexual life to the fullest. In some cases, tadalafil can be given as an agent for getting rid of other problems such as pulmonary arterial hypertension as well. Tadalafil has a longer duration of action as compared to other drugs used for the same purpose therefore, it provides long lasting erections that can last as long as up to 36 hours. 
Duration of Therapy and Prescribed Doses
Tadagra in any form i.e. tablets, pills or capsules is to be used in the same manner which is ingestion through the oral route. A tablet must be placed on the tongue and must be swallowed immediately after placing it in the oral cavity with the help of a glass of plain water. There are no hard and fast rules whether it should be taken with or without having a meal first. The drug must be taken 30 minutes to 1 hour before indulging into a sexual activity and should be taken once daily. Because it is a long acting drug, one pill is enough and the patient must not consume any more pills on the same day.
Side Effects to Expect and Warnings
The use of Tadagra may bring a couple of side effects with it in the patients. It is a high probability in the customers using Tadagra to develop a headache as well as stiffness in the nose. The patient can also complain of an upset stomach which is later coupled with episodes of diarrhea in some cases. Flushing of the face can occur and sometimes, the patient might feel dizzy and experience pain in his back. Dyspepsia has also been reported by many patients as a common effect of this drug along with pain in muscles of the body. 
Tadagra is not to be used with certain drugs for it possesses a risk of causing drug interaction along with certain agents. Drugs like hydralazine, amyl nitrite, nitroglycerin and nitroprusside all belong to the class of nitrates. These drugs are used for lowering the blood pressure and the use of these drugs along with Tadagra can cause an excessive decrease in the blood pressure along with generation of other cardiovascular diseases. Other drugs like boceprevir along with telaprevir must also not be used as these drugs have the capacity to interact with the metabolism of Tadagra and result in accumulation of it in large doses in the blood. This abnormal accumulation can lead to life risking side effects in the patients. 
Tadagra had no customer reviews made in its name by any of the customers online. This is probably because of the fact that either it is an unpopular drug among the users or it has not been properly advertised. Whatever is the reason, drugs with no confirmation of its working and about the safety of using are strongly discouraged to be used. Customer reviews guide a lot in choosing the best medicine for a certain problem since these are actually the experience of other people with the same disease with that drug. Hence, Tadagra must be avoided and other drugs that have customer reviews confirming the effectiveness and safety of usage must be preferred to it.
Price, Available Forms and Dosage
Customers can easily buy Tadagra via different pharmacies working online, one of them being www.rxmedicaments.com. Tadagra is available at this website at a discounted price and in the form of packs. Each pack consists of 10 capsules each and is priced at 39.95 US Dollars.
Delivery service is also being offered for those customers that live in other countries like America, Australia, and Canada. Two different companies offer their services in this regard which is flat for all the countries. Delivery via Registered Airmail is free for all the orders while Express Mail Service charges 16 US Dollars for its service.
Tadagra is available in the form of pills, soft gelatin capsules, and tablets. All of these formulations of Tadagra consist of tadalafil in them in either 20 mg or 40 mg potency. 2.5 mg of tadalafil per day is sufficient in order to treat erectile dysfunction however, it can be increased to 5 mg in some cases. 
- Health Guard India (P) Ltd [Internet]. Healthguardindia.com. Available from: http://www.healthguardindia.com/
- Rosenzweig EB. Tadalafil for the treatment of pulmonary arterial hypertension. Expert opinion on pharmacotherapy. 2010 Jan 1;11(1):127-32. Available from: http://www.tandfonline.com/doi/abs/10.1517/14656560903413542
- Gonzalez RR, Kaplan SA. Tadalafil for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia. Expert opinion on drug metabolism & toxicology. 2006 Aug 1;2(4):609-17. Available from: http://www.tandfonline.com/doi/abs/10.1517/17425255.2.4.609
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