- 1 About Mankind Pharma
- 2 Scientific Studies on Tadalafil
- 3 Description and Mechanism of Action of Tadalafil
- 4 Tadaforce Benefits for Erectile Dysfunction Treatment
- 5 Recommended Regimen and Doses
- 6 Side Effects and Warnings
- 7 Drug Interactions
- 8 Customer Reviews
- 9 Price, Available Tadaforce Forms, and Dosage
- 10 Reference List
- 11 Editor's Rating
Tadaforce 20 mg tablets are a sure way of getting rid of problems related to the sexual health of men, erectile dysfunction to be precise.
The drug is to be taken once daily which is enough for at least next 24 hours due to the long lasting action of tadalafil present in it. It can be associated with certain side effects like back pain, myalgia, dyspepsia and a headache. Tadaforce tablets must always be used after consulting with a doctor first as it possesses a risk of interacting with certain other drugs when taken simultaneously.
About Mankind Pharma
Mankind Pharma is an Indian based company that first started working in the year 1986. In 1995, the company started working properly as a company after being legalized a few years back in 1991. It has a turnover rate of 50000 million INR today and has over 11000 people enrolled in its company.
The company is involved in producing different products like over the counter drugs, staylong gels, condoms, tablets and others all under its name. The presence of this company has extended to 11 different countries including the gulf countries, Asia and Africa. The manufacturing unit of Mankind Pharma has working standards set as per the regulations of GMP. It aspires to produce high quality, affordable drugs that satisfy the needs of the medical world. 
Scientific Studies on Tadalafil
A research by “Safety, Efficacy, and Pharmacokinetic Overview of Low-Dose Daily Administration of Tadalafil” by Rebecca Wrishko et al studied how the administration of tadalafil in the form of small doses affected the disease along with its safety levels and other pharmacokinetic properties. There are a lot of PDE5 inhibitors commonly available in the market for treating erectile dysfunction. The complexities of behavior shown by people in relation to the sexual closeness they share forced the clinicians to develop an alternative drug regimen for administration of the agent once on a daily basis. The study was focused on finding a treatment for people who got intimate with their partners at least twice on a daily basis. Predictions were made in respect to the pharmacokinetic behavior of tadalafil when it was taken in a dose of 20 mg all at once and it was compared to the usage pattern of tadalafil derived from on-demand and as-needed clinical trials of the agent. In order to further clarify the effectiveness and safety of tadalafil administration, trials were organized in which men were given tadalafil in doses as low as 2.5 mg and 5 mg. The levels of tadalafil in plasma were to be estimated in this study and the safety and efficacy of it in low doses were to be determined from the trials. Pharmacokinetic and pharmacodynamics data was derived and it was seen that 5 mg of tadalafil, when administered in the body, produced its beneficial effects that lasted up to 24 hours. The exposure to a daily dose of tadalafil was also found to be reduced in people taking 20 mg of it and participated in sexual activity two times a week. The trials conducted to check the safety and effectiveness of tadalafil in 2.5 and 5 mg dose was given the same results as seen in studies involving 10 and 20 mg of tadalafil administration. Hence, it was successfully concluded that tadalafil, when given in low doses daily, proved to be effective as well as safe. 
Another research titled as “Combination therapy with prostacyclin and tadalafil for severe pulmonary arterial hypertension: A pilot study” by Daniele Bendayan determined the use of tadalafil in combination with prostacyclin in the treatment of pulmonary arterial hypertension. Although many new drugs have been introduced in the field of medicine that claim to cure the problem of pulmonary arterial hypertension but there are some patients who do not respond to these agents and show retrieval of the disease at once. Phosphodiesterase 5 inhibiting drugs are the new drug of choice for treating pulmonary arterial hypertension especially those who have a longer duration of action. In this study, the efficacy of these PDE5 inhibitors was to be determined when they were given in combination with prostacyclin. Four different cases of patients were selected in order for this study to proceed when each of the patients had failed to give any response to prostacyclin administration alone. Two of the patients were also suffering from Eisenmenger syndrome while one was a patient of hypertension in the lungs due to scleroderma and the last one was having histiocytosis X. All of these patients were given tadalafil in a dose of 10 mg or 20 mg in combination with the usual prostacyclin. Within a matter of three months, all the patients started showing improvements in their disease. No changes in the arterial pressure in the pulmonary arteries were detected via echocardiogram. The study was established at a small level with a low number of subjects involved but it did suggest about the efficacy of tadalafil in patients with PAH who were not responding to prostacyclin alone. 
Description and Mechanism of Action of Tadalafil
Tadalafil is an inhibitor of PDE5, an enzyme that is responsible for breaking down cGMP in the corpus cavernosum of the penis. Administration of tadalafil leads to accumulation of cGMP which causes relaxation of smooth muscles and vasodilation of the arteries in the penis. Both of these effects, when combined together, produce hard and long lasting erections in the user.
Tadaforce Benefits for Erectile Dysfunction Treatment
Tadalafil is used to treat problems related to men’s’ sexual health. It is primarily used to treat impotence in males in addition to the problem of erectile dysfunction. Administration of this agent results in an increased blood flow towards penis while relaxation of the penile smooth muscles the combination of which produces hard erections. These erections stay for a long time since tadalafil has a long duration of action. Tadalafil is also used to treat the problem of benign prostatic hyperplasia as it also works on the smooth muscles of the prostate gland. Lower urinary tract symptoms are also treated by tadalafil that usually accompanies BPH. Pulmonary arterial hypertension is also treated in both men and women by the virtue of this drug. 
Recommended Regimen and Doses
The most accurate method of consuming Tadaforce tablets is to take them about 30 to 45 minutes before getting involved in a planned sexual intercourse. This is necessary because the time interval allows the drug to get absorbed to a maximal extent into the blood and hence, more therapeutic effects are observed in the patient in this way. It should be placed in the mouth. And must be swallowed without getting it crushed or chewed. It can be taken with or without food and one-time intake of this drug is sufficient for a day. It must never be used in combination with alcohol. It works better on a patient who is sexually aroused and is not meant to gain an instant erection. 
Side Effects and Warnings
Side effects associated with Tadaforce are due to the presence of tadalafil in its composition.
In addition, the patient using this drug can also complain of an upset stomach and diarrhea. Flushing of face, dizziness, runny nose and lightheadedness can also be observed in some cases. In rare cases, disturbance in the visual acuity of one or both eyes along with tingling in the ears can also be felt. Swelling of hands and feet and pain in jaw and left arm are some other adverse effects that can be seen in people consuming Tadaforce. 
Tadaforce is capable of interacting with certain drugs due to the presence of tadalafil in its composition. The simultaneous administration of CYP 3A4 drugs with Tadaforce results in a decrease in the levels of the drug in the serum. These drugs include efavirenz, rifampin, and carbamazepine. Other drugs with similar effects include nevirapine, phenobarbital, and barbiturates. Rifabutin and phenytoin can also interact with Tadaforce if they are taken together. Nitrates like nitroprusside and nitroglycerin have a potential to interact with Tadaforce in order to produce hypotensive effects in the body. 
Customer reviews are the first thing to be checked by anyone who wishes to know about a drug online. These reviews are given by regular people on the basis of their personal experience with the drug. Therefore, the authenticity of these feedback reviews present on the internet cannot be denied especially when these reviews are posted on different independent review websites. Tadaforce tablets were, unfortunately, devoid if the customer reviews completely from any website on the internet. This means that the drug is not having any confirmation of being effective and most importantly being safe. Such type of drugs should not be just purchased blindly without knowing anything about it. Hence, it is advised to all the new customers not to use Tadaforce and stick with the famous drug consisting of tadalafil.
Price, Available Tadaforce Forms, and Dosage
Tadaforce drug is available on different websites owned by pharmacies and makes it convenient for the customers to buy it easily without facing the hassle of searching it in local markets. The drug is extremely cheap with 20 mg potency of Tadaforce priced at 0.37 US Dollar each.
Shipping is also offered for Tadaforce in order to facilitate overseas customers residing in areas like the United States, Australia, and Canada. Two types of shipping are offered by the websites one of which is fast shipping that charges 60 USD and takes 1 to 2 weeks to deliver. The other one takes up to a month to deliver with charges of 30 USD.
Tadaforce is manufactured in the form of tablets each consisting of either 10 mg or 20 mg of tadalafil. The use of tadalafil must be carried out carefully in order to prevent an overdose. For daily use in the treatment of erectile dysfunction, 2.5 mg of tadalafil is enough, to begin with. In some cases, its dose can pe increased to 5 mg per day but not more than this, in any case, is recommended.
- Company Overview [Internet]. Mankindpharma.com. Accessible from https://www.mankindpharma.com/company/companyoverview
- Wrishko R, Wong D, McGill J, Sorsaburu S, Strawbridge A. Safety, efficacy, and pharmacokinetic overview of low‐dose daily administration of tadalafil. The journal of sexual medicine. 2009 Jul 1;6(7):2039-48. Accessible from: http://onlinelibrary.wiley.com/doi/10.1111/j.1743-6109.2009.01301.x/full
- Bendayan D, Shitrit D, Kramer MR. Combination therapy with prostacyclin and tadalafil for severe pulmonary arterial hypertension: a pilot study. Respirology. 2008 Sep 1;13(6):916-8. Accessible from: http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1843.2007.01176.x/full
- Tadalafil [Internet] Wikipedia.com. Accessible from: https://en.m.wikipedia.org/wiki/Tadalafil
- What is Tadaforce? [Internet]. Tabletwise.com. Accessible from: http://www.tabletwise.com/tadaforce-tablet
- Tadaforce Tablet Review: Don’t Be Tricked Into Ineffective Brand of Tadalafil [Internet]. Pillrankings.com. Accessible from: https://pillrankings.com/tadaforce-review-dont-tricked-ineffective-brand-tadalafil/
- Tadalafil (erectile dysfunction) – oral, Cialis [Internet]. Medicinenet.com. Accessible from: http://www.medicinenet.com/script/main/mobileart.asp?articlekey=45732
- Tadaforce 20mg [Internet]. Medsplan.com. Accessible from: http://www.medsplan.com/DrugsDetailsPage/TADAFORCE-20MG-TABLET/Tadalafil%20