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Tadacip 20mg/10mg Pills Cipla Reviews: Price-Friendly Effective Tadalafil Treatment

by Jacob Thompson 2017-03-01

Tadacip 20mg/10mg is the product from the manufacturer Cipla Limited, which is an Indian multinational company with numerous accreditations from reputable international drug regulating agencies such as the US FDA, UK MHRA, WHO-GMP, and a number of others.

Tadacip is one of the generic products containing the active ingredient Tadalafil, which is a potent PDE5 (Phosphodiesterase Type 5) inhibitor used in the treatment and the management of the symptoms of Erectile Dysfunction (ED) of various causes [1].

There are many factors affecting the onset of ED in patients and PDE5 inhibitors are effective in dealing with all ED types.

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Aside from Tadalafil being effective in the treatment of the sexual dysfunction, it is also being used as a blood pressure-lowering medication for patients diagnosed with Pulmonary Hypertension and also used as a diuretic in patients with obstructive prostates leading to difficulty in urinating secondary to Benign Prostatic Hypertrophy (BPH) [1][2].

Tadacip manufactured by Cipla Limited is made in two doses, the 10 mg and the 20 mg. The Tadalafil medication by Cipla is only made in oral pill form. Tadalafil intake is advised only when needed, much like the intake of similar PDE5 inhibitor medications such as Sildenafil Citrate and Vardenafil [2][3]. Tadacip is widely distributed around the globe, considering the reputation and the status of the manufacturing company, which is accredited by numerous drug agencies worldwide, promoting its products’ sale and export in numerous locations globally.

Information About Cipla Limited

Cipla Limited is a pharmaceutical company which was inducted in 1935 and with a focus on the development and the marketing of new product formulations for its clientele [4]. The company offers a wide range of products including pharmaceutical products for both human and animal use, pesticides food and beverages, baked goods, cosmetics (oral hygiene products and personal care products), detergents, and room fresheners [4].

Since Cipla is a global brand which supplies to some 100 countries of the world [5], as per the information from NDTV, 55% of the company’s revenues come from its sales overseas [4]. Cipla is currently home to 5,500 products including treatments for diseases such as cancer, Alzheimer’s disease, Parkinson’s disease, arthritis, cardiovascular, pediatric diseases, general medicine, and others [4]. Aside from making its own products, Cipla Limited also provides consultation services for product and material preparations, plus it is also a known supplier of plant equipment [4].

Cipla Main Office

Cipla Main Office

Today, Cipla has 35 facilities for product manufacturing (APIs and formulations) [6], a number are located in India, while the others are scattered in countries such as the US, Belgium, and South Africa [5]. Cipla is well-known for its production of generic AIDS medicine which even the poor can afford [5].

Yearly, Cipla is producing 23 billion units of tablets and capsules, 110 million units of fill seal eye drops and aerosols, 750 million units of respules, 94 million units of oral liquid formulations, 45 million units of pre-filled syringes, 5 million units off lyophilized injections, and 1000 MT of APIs (active pharmaceutical ingredients) [6]. To date, the company has acquired numerous important accreditations from a large number of food and drug regulatory institutions all over the world [7]. The company has the approvals of the US FDA, Geneva WHO, UK MHRA, Australia TGA/APVMA, South Africa MCC, Slovak Republic SUKL, Germany PIC, Saudi Arabia MOH, Canada Department of Health, Brazil ANVISA, Colombia INVIMA, Uganda NDA, Denmark Medical Agency, amongst many others [7].

Studies on Tadalafil for Medical Applications

One of the effective PDE5 (Phosphodiesterase Type-5) inhibitors used for the management of patients exhibiting symptoms of erectile dysfunction (ED) is Tadalafil. There are numerous studies conducted to establish the effectiveness of the medication and one of the earlier studies for the drug was that of Padma-Nathan et al in 2001, “On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunction” [8]. The study by Padma-Nathan et al explored the effectiveness of the on-demand use of Tadalafil (IC351/Cialis) for the management of the erectile dysfunction of the patients suffering from the disease. 179 patients diagnosed with ED were randomized to either Tadalafil C351 in doses of 2 mg, 5 mg, 10 mg, or 25 mg; or placebo and made to take the drug as needed in a period of 3 weeks [8]. The patients were evaluated using the IIEF (International Index of Erectile Function) questions 3 and 4 (Q3 and Q4) [8]. According to the results of the study, Tadalafil/IC351 gave significant improvements in the IIEF baseline scores for Q3 and Q4 compared to placebo, although for the Q4, IC351 was not able to improve the scores for its 2 mg dose [8]. There were no significant changes observed for the laboratory values, ECG values, blood pressure and other parameters which could significantly affect the patients [8]. According to the authors’ conclusion, Tadalafil doses of up to 25 mg are effective in the management of erectile function and were well-taken by the patients [8].

Tadalafil use is not limited to erectile dysfunction. In fact, it is also an approved medication for the treatment of several other conditions such as pulmonary arterial hypertension (PAH) and also for the improvement of the symptoms presented in patients diagnosed with benign prostatic hyperplasia (BPH). Patients with BPH, when treated with Tadalafil, had improvements in their urinary symptoms as a product of the relaxing effect of Tadalafil in smooth muscle cells of even the bladder. In the study of Donatucci et al in 2011, “Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a 1-year, open-label extension study” studied the effectiveness of Tadalafil when administered daily for patients with BPH [9]. The cohort study evaluated the effectiveness of 5 mg Tadalafil when administered daily for a year to patients with lower urinary tract symptoms accompanying their benign prostatic hyperplasia (BPH) cases [9]. 427 men were included in the study and were administered with placebo or a daily dose of Tadalafil with 2.5 mg, 5 mg, 10 mg, or 20 mg [9]. Patient response and drug effectiveness were checked every 3 months [9]. Out of the initial participants, 299 patients were able to complete the 1-year study and there were the presence of treatment-emergent adverse effects in patients ranging from mild to moderate severity (dyspepsia, GERD, headache, back pain, hypertension, cough, and sinusitis) [9]. Due to these side effects, 22 patients discontinued treatment [9]. Speaking of the results regarding the effectiveness of Tadalafil for the condition, the post-void residual volume was improved by Tadalafil, and the drug also improved the IPSS (International Prostate Symptom Score) score, IPSS quality of life, and BPH impact index [9]. The authors concluded that Tadalafil, when taken daily for the management of BPH/LUTS is effective in the improvement of the condition in patients diagnosed with the disease [9].

Description and Mechanism of Action of Tadalafil

Tadalafil is an effective drug in helping patients regain their erectile function lost through the disease ED. Since the drug belongs to the category of PDE5 inhibitors, Tadalafil is known to block the action of the enzyme PDE5 which breaks down the cGMP (cyclic guanosine monophosphate) found in the penile walls, which is largely responsible for the maintenance of the erectile response in patients.

Since cGMP levels in the penile tissue are maintained high, the patients are able to regain their erectile control, since there is no PDE5 which destroys the cGMP in the penile tissue. The effect of cGMP is simple; it stimulates the relaxation of the smooth muscles of the penis and encourages the increased blood flow in the area, leading to an erection. Since PDE5 inhibitors like Tadalafil have a sustained effect in patients and helps the patients maintain the erectile response for as long as 36 hours.

Tadacip Effects for Erectile Dysfunction

Tadalafil is prescribed to the patients by physicians for the treatment of erectile dysfunction (ED) due to its effectiveness in restoring the erectile function in patients with the disease. Patients suffering from impotence are able to regain their erectile function while using Tadalafil.

The drug is used on an on-demand basis and is not actually a cure for erectile dysfunction, although the product is very effective in improving the symptoms of erectile dysfunction in the patients prescribed with the medication. Patients can expect to have their control over their erectile function again, which was diminished or loss due to the progression of their ED condition.

Therapy Duration and Suitable Doses

The initially recommended dose for Tadalafil use is 10 mg, although the dose can be increased to up to 40 mg per use. Patients should not be the one to increase the dose, though; they should seek the advice of their physicians regarding the increase of Tadalafil dose in patients.

For erectile dysfunction, symptom relief for benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH), the patients may use Tadalafil once daily but the dose depends on the recommendation of the doctor and is usually low (2.5 mg or so).

Currently, there is no recommendation for the fixed duration of Tadalafil use in patients, but the patients are using the product long-term for the relief of their conditions, especially due to the fact that Tadalafil does not actually cure ED but only gives temporary relief for the symptoms.

Side Effects and Warnings

Medications are almost always with side effects and these side effects are often inevitable. Although the risk of side effects are given in every use of medications like Tadalafil and other PDE5 inhibitors, the doctors still prescribe the medications because they believe that the benefits of the drugs outweigh the side effects.

Usual side effects patients can expect with Tadalafil use are as follows: headache, dyspepsia, back pain, sinusitis, stuffy nose, facial flushing, sore throat and GI upset [1,3,9]. Aside from these common side effects, though, the patients may also observe more serious adverse events which they should report to their physicians immediately like chest pain (or heart attack-like symptoms), persistent nausea, sudden vision loss, irregular heartbeat, difficulty in breathing, dysphagia, tinnitus, or sudden hearing loss [2].

The patients may not experience all of these symptoms and in most cases, the patients are asymptomatic of the side effects. But when they notice that these side effects persist and do not go away, they should report it to their physicians and seek medical help.

Drug Interactions

Patients are advised to avoid alcoholic drinks and any medication which contains nitrates/nitrites/or any similar medication. Drugs which contain nitrates are commonly those indicated for lowering the blood pressure, medications for angina, and cardiovascular medications [2]. Recreational drugs which contain nitrates should also be avoided in order to avert critical lowering of the patients’ blood pressure.

Medications indicated for depression (Rifampin, Rifabutin, Rifapentine), antibiotics (Clarithromycin, Erythromycin, etc.), systemic antifungal medication (ketoconazole, itraconazole, etc.), prostate drugs, and HIV medications (Atazanavir, Darunavir, Ritonavir) should also not be taken with Tadalafil medications as they can all interact harmfully with the medication [2]. Patients should also not take any other PDE5 inhibitor medication along with Tadalafil as the resulting interaction can cause toxicity or exacerbate the side effects of the drug.

Customer Reviews

Tadacip 20mg/10mg is a popular medication among online users due to the popularity of the brand and the manufacturer. There were varied client experiences for Tadacip use by patients. There were several product reviews available on Alldaychemist.com and they were varied responses from the users of Tadacip.

The first user (“Beast”) rated Tadacip 3 out of 5 because according to him, the drug was not as effective than its brand-name Cialis counterpart. He mentioned that the product worked slower, gave him random erections, and caused him to fail in his performance. Also, the user mentioned that the drug did not last as long as it was advertised, as the effects of the drug only took less than 24 hours based on his experience.

Another reviewer, though, gave a different review from the first user. “Matthew” rated the product 5 out of 5 due to its effectiveness and even mentioned that the effect of the drug feels “natural”. Unlike the first user, “Matthew” mentioned that Tadacip lasted him up to 48 hours.

Another positive response for Tadacip was from a commenter on a thread from the forum site, Pharmacyreviewer.com. according to the consumer, he tried the 20 mg Tadacip ad was pleased with the results of the drug. He ordered the drug due to its affordability and was pleased that he did so. The only downside to his use was the headache and aside from that, he mentioned that the effect was just the same as the brand-name version of the drug.

The reviews for Tadacip were generally on the positive side. Not all drugs will work the same on every client, as there are numerous factors affecting the drug’s effectiveness. But overall, based on the customer responses for Tadacip 20mg/10mg, I think that the drug is highly recommendable for patient use (although only when prescribed).

Price, Available Forms and Dosage

It is not hard to find a Tadacip product online since there are numerous vendors selling the product. Some of the vendor prices (from Alldaychemist.com and Pharmacy2home.com) are shown below and in general, the price for Tadacip 20mg/10mg is quite affordable.

Tadacip Prices

Tadacip Prices

Alldaychemist.com has Tadacip for at $1.20-$1.50 per pill (4-pill minimum) and also offers freebies to every purchase. On the other hand, Pharmacy2home.com has its Tadacip for $1.50 each pill but for a minimum of 20 pills. Of course, online drugstores like these offer lower prices for larger orders, so buyers can take advantage of that.

Tadacip Shipping Rate

Tadacip Shipping Rate

As for the shipping rate, Internet pharmacies often offer a flat shipping rate for all the orders regardless of the destination country, like the flat shipping rate from this online store. Pharmacy2home.com asks for $16 for the shipping fee and it is for the regular shipping method. Online stores usually offer two shipping options, but there are shops like Pharmacy2home.com which offers only one.

Tadacip is available for international shipping so patients planning to save on Tadalafil cost may order the product from reputable online sites. Buyers from the US, Australia, and Canada may be able to purchase the product; also clients from almost all parts of the world. Aside from being widely distributed online, since Cipla is a global brand, the company made its Tadacip locally available in a number of countries aside from India, including the USA, European countries, Australia, South Africa, Canada, Pakistan, Malaysia, Singapore, Thailand, Uruguay, and the United Kingdom. Patients just have to search their local drugstores for the availability of Tadacip in their localities.

Reference List

  1. 1mg.com: TADACIP 20 MG TABLET. Accessible at: https://www.1mg.com/drugs/tadacip-20-mg-tablet-36043
  2. Alldaychemist.com: Tadacip – 20mg. Accessible at: https://www.alldaychemist.com/tadacip.html
  3. Tadacipgroup.com: Tadacip® (Tadalafil). Accessible at: http://www.tadacipgroup.com/
  4. Profit.ndtv.com: Cipla Limited. Accessible at: http://profit.ndtv.com/stock/cipla-ltd_cipla/reports
  5. En.wikipedia.org: Cipla. Accessible at: https://en.wikipedia.org/wiki/Cipla
  6. Cipla.com Plants & Capacities. Accessible at: http://www.cipla.com/en/corporate-information/plants-capacities.html
  7. Cipla.com: At a Glance. Accessible at: http://www.cipla.com/en/corporate-information/at-a-glance.html
  8. Padma-Nathan H, McMurray JG, Pullman WE, Whitaker JS, Saoud JB, Ferguson KM, Rosen RC. On-demand IC351 (Cialis™) enhances erectile function in patients with erectile dysfunction. International journal of impotence research. 2001 Feb 1;13(1). Accessible at: http://web.a.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=09559930&AN=9014274&h=SkT1wwednm3W2UEwCauWGV91VoBJ0C328f3kWl4lhArwF%2fxDhCAdEyo50oQ18zr36GQWjwZguiKMJ5w2aPxw%2bw%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d09559930%26AN%3d9014274
  9. Donatucci CF, Brock GB, Goldfischer ER, Pommerville PJ, Elion‐Mboussa A, Kissel JD, Viktrup L. Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: A 1‐year, open‐label extension study. BJU international. 2011 Apr 1;107(7):1110-6. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2010.09687.x/full

Editor's Rating

Overall Score
Although it is hard to decide which Tadalafil product to patronize, choosing Tadacip 20mg/10mg is a no-brainer since it is from a highly reputable, multinational, pharmaceutical giant, which has acquired a great number of approvals and accreditations from international drug agencies. The product, Tadacip, also had many reviews for its effectiveness; most of the users with an experience with the drug rave about its lasting effect and efficiency when used. Although there are negative reviews as well, the negative comments about any drug always exist, as drugs are not 100% effective to 100% of the patients 100% of the time. 5 out of 5 is the rating I am giving the product due to its manufacturer’s amazing portfolio. Cipla Limited is no ordinary pharmaceutical company; although it is mainly producing generics, it upholds quality and high-standard practices for the manufacturing and the distribution of its products. It’s not every day we get to see a company with such numerous approvals and certifications; for that alone, I am duly impressed. I highly recommend Tadacip use to patients prescribed with the drug for ED.
RXLEAKS Review - 5 out of 5 stars by
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  • loni coleti

    You can have 4 pils at $2.6 = $0.65 for one at: globalpharmastore.com/product/tadacip-tadalafil/